Depleting arginine as a first-line cancer therapy

Polaris Pharmaceuticals is evaluating its lead therapeutic protein—pegargiminase, a novel targeted cancer therapy that depletes circulating arginine—in combination with standard chemotherapies and immuno-oncology drugs in various cancers, including hepatocellular carcinoma and mesothelioma.

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Polaris Pharmaceuticals

Polaris Pharmaceuticals, Inc. (a subsidiary of Polaris Group) is a biopharmaceutical company specializing in the research and development of novel treatments for cancer. Pegargiminase (ADI-PEG 20) is a potential first-in-class targeted cancer therapy in late-stage clinical development for a wide range of cancers, especially hepatocellular carcinoma and malignant pleural mesothelioma. Based in San Diego, California, USA, Polaris Pharmaceuticals collaborates with major pharmaceutical companies and more than 40 cancer centers worldwide. The multinational Polaris Group also includes high-quality in-house current good manufacturing practice (cGMP) manufacturing through wholly owned subsidiaries. Its global clinical trial program is supported by a highly experienced management team and renowned scientific advisors, including James Allison, who was awarded the 2018 Nobel Prize in Physiology or Medicine for his pioneering work on cancer immunotherapy.

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