Available for Licensing: A Human Progenitor Mast Cell Line for Allergic and Fibrotic Research and Therapeutic Screening
The HPS-1 proMastocyte (HPM) cell line, containing an HPS-1 mutation, is the first mast cell line shown to constitutively release fibrotic proteins. This cell line serves as a model to study early mast cell development or fibrosis, or as a tool to screen therapeutic compounds for pulmonary fibrosis.
Hermansky-Pudlak Syndrome type-1 (HPS-1) is a rare genetic disorder that affects around 1 in 500,000 people worldwide and 1 in 1,800 Puerto Ricans. Patients with HPS-1 display oculocutaneous albinism, bleeding due to platelet abnormality, and pulmonary fibrosis. Those that develop pulmonary fibrosis often succumb and live no more than a decade after early onset of breathing problems.
Scientists at the National Institute of Allergy and Infectious Diseases (NIAID) have developed the HPS-1 proMastocyte (HPM) cell line, containing an HPS-1 mutation. This cell line resembles a progenitor mast cell with reduced granule formation, significant chemotactic ability, and is the first mast cell line shown to constitutively release cytokines, chemokines, and most importantly fibrotic proteins. This cell line serves as a model to study granule formation, early mast cell development, chemotaxis and mechanisms controlling synthesis of molecules contributing to fibrosis, as well as a screening tool to identify target compounds for the treatment of pulmonary fibrosis.
The cell line is available as live cells approximately 3-4 million cells per sample in a T25 Flask.
First progenitor mast cell line known to produce fibrotic elements
Progenitor mast cell line with rapid growth, no cytokine stimulation needed. Cell doubling time of 2–3 days
Inventors: Arnold S. Kirshenbaum and Dean D. Metcalfe, both of NIAID
Kirshenbaum AS et al. Immunophenotypic and Ultrastructural Analysis of Mast Cells in Hermansky-Pudlak Syndrome Type-1: A Possible Connection to Pulmonary Fibrosis. PLoS One. 2016, Jul 26;11(7): e0159177, PMID 27459687
HHS Reference No. E-270-2016/0, available as a Biological Material
Licensing Contact: Dr. Benjamin Hurley, (240) 669-5092, firstname.lastname@example.org .