Optimized variants of the broadly neutralizing HIV-1 gp41 antibody, 10E8
Optimized variants broadly neutralizing HIV-1 gp41 antibody, 10E8, exhibit improved manufacturing properties, while preserving neutralizing breadth and potency.
Scientists at the National Institute of Allergy and Infectious Diseases (NIAID) recently discovered a human neutralizing antibody, 10E8, that binds to the GP41 protein of HIV-1 and prevents infection by HIV-1. 10E8 potently neutralizes up to 98% of genetically diverse HIV-1 strains.
By engineering the 10E8 antibody, NIAID scientists have improved the properties of 10E8 that affect manufacturability, such as solubility, while preserving its neutralizing breadth and potency.
10E8 variants are useful for passive protection from infection, as therapeutics, and as a tool for vaccine development. This technology is available for licensing for commercial development in accordance with 35 U.S.C. 209 and 37 CFR Part 404.
Potential Commercial Applications:
Passive protection to prevent HIV infection
Passive protection to prevent mother-to-infant HIV transmission
Gene-based vectors for anti-gp41 antibody expression
Therapeutics for elimination of HIV infected cells that are actively producing virus
Among the most potent and broadly neutralizing human antibodies isolated to date
Broad reactivity and high affinity to most HIV-1 strains
Improved manufacturability relative to the natural 10E8 antibody
In vivo data available (animal)
Inventors: Peter D. Kwong (NIAID), Young Do Kwon (NIAID), Ivelin S. Georgiev (NIAID), Gilad A. Ofek (NIAID), Baoshan Zhang (NIAID), Krisha McKee (NIAID), John Mascola (NIAID), Gwo-Yu Chuang (NIAID), Sijy O’Dell (NIAID), Robert Bailer (NIAID), Mark Louder (NIAID), Mangaiarkarasi Asokan (NIAID), Richard Schwartz (NIAID), Jonathan Cooper (NIAID), Kevin Carlton (NIAID), Michael Bender (NIAID), Mark Connors (NIAID), Amarendra Pegu (NIAID), Lisa Kueltzo (NIAID), Tatyana Gindin (Columbia University), and Lawrence Shapiro (Columbia University).
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IN Application No. 201837016184
ZA Application No. 2018/02875
AU Application No. 2016349392
Kwon YD, et al. PMID 27053554
Licensing Contact: Dr. Vince Contreras, 240-669-2823; firstname.lastname@example.org