Stabilized Group 2 Influenza Hemagglutinin Stem Region Trimers and Uses: Licensing Opportunity

Researchers at the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases (NIAID) have designed influenza vaccine candidates based on group 2 influenza hemagglutinin (HA) proteins. These group 2 HA proteins were engineered to remove the highly variable head region and stabilize the remaining stem region. The researchers then fused the engineered group 2 HA stabilized stem with a ferritin subunit. These immunogens elicit cross-reactive antibodies to group 2 influenza viruses and could be used in combination with group 1 HA stem-ferritin immunogens as a universal influenza vaccine.

Researchers at the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases (NIAID) have designed influenza vaccine candidates based on group 2 influenza hemagglutinin (HA) proteins. These group 2 HA proteins were engineered to remove the highly variable head region and stabilize the remaining stem region.  The researchers then fused the engineered group 2 HA stabilized stem with a ferritin subunit. The resulting fusion protein can self-assemble into nanoparticles which display group 2 HA stem domain trimers on their surface.

These immunogens elicit cross-reactive antibodies to group 2 influenza viruses and could be used in combination with group 1 HA stem-ferritin immunogens as a universal influenza vaccine. Interestingly, a recent study by Andrews et al., Sci. Immunol. 2, eaan2676 (2017), suggests that cross-reactive group 1/group 2 HA stem antibodies may be more likely to be elicited in humans by a group 2 HA immunogen.

This technology is available for licensing for commercial development in accordance with 35 U.S.C. § 209 and 37 CFR Part 404, as well as for further development and evaluation under a research collaboration.

 

Potential Commercial Applications: 

  • Use as a broadly protective influenza vaccine

Competitive Advantages: 

  • Elicits antibodies to both group 1 and group 2 influenza A viruses

  • Nucleic acid or recombinant protein-based vaccine

  • Increased ease of production compared to current seasonal influenza vaccines

Development Stage:

  • In vivo (animal studies)

Inventors:  Jeffrey C. Boyington, Barney S. Graham, John R. Mascola, Hadi M. Yassine, Syed M. Moin, Lingshu Wang, Kizzmekia S. Corbett, Masaru Kanekiyo (all from NIAID).

Intellectual Property:  U.S. Provisional 62/383,267 filed 2 September 2016 and PCT Patent Application No. PCT/US2017/049894 filed 1 September 2017 (pending).

Licensing Contact: Dr. Amy Petrik, 240-627-3721; amy.petrik@nih.gov

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NIAID Technology Transfer and Intellectual Property Office

NIAID’s technology transfer office, TTIPO, is a one-stop resource for organizations interested in partnering with NIAID to access, develop, and manage the translation of research discoveries into medically beneficial products. TTIPO seeks to expand NIAID’s innovation pipeline with existing and new partners in areas such as newly emerging and re-emerging infectious diseases (e.g., dengue, Zika, Ebola, influenza, methicillin-resistant Staphylococcus aureus and HIV/AIDS), biodefense (e.g., smallpox and anthrax), and immune-mediated diseases (e.g., asthma and allergy).

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