Go to the profile of Abide Therapeutics

Abide Therapeutics

 

About Abide Therapeutics

Abide Therapeutics is a clinical-stage biotechnology company focused on transforming the lives of patients with serious unmet medical needs by developing first-in-class, small-molecule medicines targeting the serine hydrolase enzyme superfamily. This family of 250 enzymes regulates signaling pathways in the brain, digestive tract, and immune system. We use our unique platform that leverages the shared catalytic mechanism characteristic of the serine hydrolases to discover selective inhibitors from our highly tailored library. Our unparalleled understanding of serine hydrolase biology coupled with sophisticated chemoproteomic and metabolomic methods enables us to rapidly identify and validate new targets and efficiently develop both biomarkers and drug candidates for first-in-class clinical mechanisms. Our most advanced program is an inhibitor of MGLL, an enzyme that regulates neurotransmitters. Dysregulation of neurotransmitter tone is a general feature of brain damage in several diseases. The initial indications for our MGLL inhibitor are Tourette Syndrome, NMO, and MS spasticity. We see these as gateway indications, data from which may lead to other neurology indications such as Parkinson’s disease and ALS. We are also developing follow-on MGLL candidates and identifying inhibitors for new serine hydrolase targets for liver disease and oncology.

Therapeutic Areas

Central Nervous System Inflammation Metabolic Oncology

Technologies

Small molecules

Company Type

Biotechnology – Therapeutics

State of Ownership

Private

Sponsorship Group

Networker

Influencer Of

Topics

Editions participated in:

November 2017